America's addiction crisis is being ushered into a dangerous new era by rising levels of polysubstance abuse, as more people become addicted to deadly combinations of synthetic opioids and stimulants.

Polysubstance use has become a defining feature of the U.S. overdose crisis in the past decade. While not every overdose involves multiple substances, a significant and growing proportion includes ...

Beyond sexual health risks, chemsex is linked to serious mental health consequences influenced by how often, how intensely and how substances are used.

PWH with substance use face increased risks of housing instability, food insecurity, and transportation issues compared to controls. Polysubstance users have higher odds of depression, mania, and ...

The moment she saw him, Kelly Celata feared the man was dead from a drug overdose. It was a warm July morning last summer, and a man in his 30s was stretched out on the pavement near downtown Brockton ...