Non-protein-coding genes have been linked to a hereditary condition, retinitis pigmentosa, that causes progressive blindness.

Understanding human gene function in living organisms has long been hampered by fundamental differences between species.

Discover the innovative TECHNO platform for full-length gene humanisation, enhancing models for human gene function.

Researchers at The University of Tokyo developed TECHNO, a two-step genome editing strategy that replaces entire mouse loci ...

Biologists have discovered a new type of RNA-splicing regulation that helps to determine which protein-coding exons will be included in messenger RNA transcripts. RNA splicing is a cellular process ...

Retinitis pigmentosa (RP) is a genetic eye disorder affecting around one in 5,000 people worldwide. It typically begins with ...

Thousands of new genes are hidden inside the “dark matter” of our genome. Previously thought to be noise left over from evolution, a new study found that some of these tiny DNA snippets can make ...

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this ...

Humanized mouse models are vital for studying human gene function, but fully replacing mouse genes with complete human ...