In a collaboration between several labs at UNC Lineberger, researchers have defined cancer-associated fibroblast (CAF) subtypes that are clinically robust, prognostic, and predictive of immunotherapy ...

Spatial transcriptomics (ST) technologies reveal the spatial organization of gene expression in tissues, providing critical insights into development, neurobiology, and cancer. However, the high cost ...

The integration of single-cell and spatial transcriptomics with advanced metabolic profiling tools has revolutionized the ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

What do healthy bone marrow cells in children look like? For the first time, researchers have mapped this out. Scientists at the Princess Máxima Center examined nearly 91,000 individual bone marrow ...

Immunotherapy—which activates the body's own immune system to kill cancer cells—has not worked well against a rare and fatal liver cancer, but a new study finds an existing FDA-approved drug may allow ...

These findings underscore the promise of single-cell transcriptomic biomarkers to disentangle the systemic and cell-intrinsic components of immune ...