Abstract: The Nelder-Mead simplex method is a well-known algorithm enabling the minimization of functions that are not available in closed-form and that need not be differentiable or convex.

The MarketWatch News Department was not involved in the creation of this content. BOLOGNA, Italy and MUNICH, Jan. 14, 2026 /PRNewswire/ -- Alfasigma S.p.A. ("Alfasigma"), a global pharmaceutical ...

Dara-Abasi Ita writes about trading and investing for Investopedia and Investing.com, and he is an editor at Lawverse magazine. He has written about financial topics, including private equity, asset ...

Researchers at Google Cloud and UCLA have proposed a new reinforcement learning framework that significantly improves the ability of language models to learn very challenging multi-step reasoning ...

AI Unity boss who once called out the 'idiocy' of the metaverse now says his company's new AI tech 'will enable developers to prompt full casual games into existence with natural language only' AI A ...

Moderna said on Tuesday its updated COVID-19 vaccine formulation elicited a strong immune response in all adults aged 65 and older, as well as in individuals aged 12 to 64 with at least one underlying ...

Most DIYers and even some pros don’t know this little-known plastering method that makes the job faster, smoother, and easier. In this video, you’ll learn step by step how to apply this technique so ...

The 2025-2026 COVID-19 vaccine formulation targets the SARS-CoV-2 sublineage LP.8.1, in line with FDA guidance to more closely match circulating strains1 Shipping of the LP.8.1-adapted vaccine will ...

CAMBRIDGE, MA / ACCESS Newswire / July 30, 2025 / Moderna, Inc. (NASDAQ:MRNA) today announced that the European Commission (EC) has granted marketing authorization for the updated formulation of the ...

July 25 (Reuters) - The European Union's drug regulator has recommended approval of Moderna's (MRNA.O), opens new tab updated formulation of COVID-19 shot Spikevax, the vaccine maker said on Friday.