PD-1 and PD-L1 in cancer immunotherapy: clinical implications ...
The PD-1/PD-L1 pathway plays an important role in autoimmune diseases, virus infection, transplantation immunology, and tumor immunity 1, 21 – 23. Under normal conditions, the PD-1/PD …
Immune Checkpoint Inhibitors - NCI - National Cancer Institute
Immune checkpoint inhibitors are a type of immunotherapy that block immune checkpoint proteins from binding with partner proteins. Learn about the cancers treated with checkpoint inhibitors and the side …
PD-1 and PD-L1 inhibitors - Wikipedia
The concept of blocking PD-1 and PD-L1 for the treatment of cancer was first published in 2001. [6] Pharmaceutical companies began attempting to develop drugs to block these molecules, and the first …
Targeting PD-1/PD-L1 in cancer immunotherapy: An effective ...
Jul 1, 2023 · Over the past few years’ rapid development in cancer immunotherapy has opened a new avenue in cancer treatment. Blockade of PD-1 and PD-L1 has become a potential strategy that …
PD-1 protects expanding human T cells from premature ...
Feb 26, 2026 · While the checkpoint function of PD-1 has profound implications for cancer immunotherapy, the role of PD-1 in regulating newly activated T cells remains unclear.
Immune Checkpoint Inhibitors and Their Side Effects
Immune checkpoint inhibitors, like PD-1 or PD-L1 inhibitors, are treatments that help the immune system recognize and attack cancer cells. Learn more here.
Use of PD-1 vs PD-L1 Inhibitors in Patients With Cancer
Dec 26, 2019 · This systematic review and meta-analysis of randomized clinical trials examines use of programmed cell death 1 (PD-1) vs programmed cell death–ligand 1 (PD-L1) treatment in patients …
Assessing the Pharmacological and Pharmacogenomic Data of PD ...
Aug 10, 2025 · Background/Objectives: Advances in understanding immune checkpoint pathways and tumor immune biology have enabled the development of immune checkpoint inhibitors (ICIs), …
A Common Drug May Make Cancer Immunotherapy Work Better
1 day ago · By identifying vesicle-associated PD-L1 trafficking as a changeable factor in immune escape, this research points to a new strategy for overcoming resistance to cancer immunotherapy. …
Interplay Between Exosomes and the PD-1/PD-L1 Axis in ...
Feb 1, 2026 · Semantic Scholar extracted view of "Interplay Between Exosomes and the PD-1/PD-L1 Axis in Hepatocellular Carcinoma: Implications for Immune Escape and Immunotherapy" by Minghao …